Peer-reviewed veterinary case report
Receptor protein levels in dog adrenal tumors and surgery outcomes
By Harding, Kayla et al.·Published in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire·2021·University of Florida College of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: C-kit, flt-3, PDGFR-β, and VEGFR2 expression in canine adrenal tumors and correlation with outcome following adrenalectomy.
- Species:
- dog
Plain-English summary
A study looked at dogs with adrenal tumors to see if certain proteins (receptor tyrosine kinases) could predict how aggressive the tumors were and how well dogs would do after surgery to remove them. They found that while some of these proteins were present in the tumors, their levels were not higher than in normal adrenal tissue, and they didn't seem to affect survival after surgery. This suggests that these proteins might not be useful for predicting outcomes, but treating the tumors by blocking these proteins could still be a potential option.
People also search for: dog adrenal tumor treatment · canine adrenalectomy outcome · dog cancer survival rates
Abstract
The objective of this retrospective study was to evaluate the expression of receptor tyrosine kinases (RTKs) in canine adrenal tumors and correlate this expression with features of tumor aggressiveness and survival in dogs undergoing adrenalectomy. Forty-three canine adrenal tumors were evaluated for expression of c-kit, fms-like tyrosine kinase 3 (flt-3), platelet-derived growth factor receptor-β (PDGFR-β), and vascular endothelial growth factor receptor 2 (VEGFR2) using immunohistochemistry. Tumor RTK staining characteristics were compared to normal adrenals. Medical records were reviewed for data regarding patient outcome and tumor characteristics. Expression of c-kit, flt-3, PDGFR-β, and VEGFR2 was detected in 26.9%, 92.3%, 96.2%, and 61.5% of cortical tumors and 0%, 63.2%, 47.4%, and 15.8% of pheochromocytomas, respectively. Expression of RTKs was not significantly increased when compared to normal adrenals and did not correlate with survival after adrenalectomy. Receptor tyrosine kinases are not overexpressed in canine adrenal tumors compared to normal adrenal tissue. Therapeutic inhibition of these receptors may still represent an effective approach in cases where receptor activation is present.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34602732/