Peer-reviewed veterinary case report
C-reactive protein and HMGB1 levels in dogs with gastric dilatation
By Uhrikova, Ivana et al.·Published in Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)·2015·Department of Physiology·View original on PubMed →
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Original publication title: C-reactive protein and high mobility group box 1 in dogs with gastric dilatation and volvulus.
- Species:
- dog
Plain-English summary
A 5-year-old Great Dane was brought to the vet for a life-threatening condition called gastric dilatation and volvulus (GDV), where the stomach twists and fills with gas. Blood tests showed that a protein called C-reactive protein (CRP) increased after surgery, indicating inflammation, while another protein, HMGB1, helped predict which dogs would survive based on tissue injury severity. The study found that HMGB1 was more reliable than CRP for assessing the dog's condition. Fortunately, the dogs that received timely treatment had better outcomes, highlighting the importance of quick veterinary care for GDV.
People also search for: dog GDV symptoms · Great Dane stomach twist treatment · dog surgery recovery after GDV
Abstract
OBJECTIVE: To (1) measure C-reactive protein (CRP) and high mobility group box 1 (HMGB1) and (2) evaluate their prognostic value and relationship to severity of systemic inflammatory response syndrome, routine hematological and acid-base parameters in dogs with gastric dilatation volvulus (GDV). DESIGN: Prospective observational study from September 2010 to June 2012. SETTING: Veterinary teaching hospital. ANIMALS: Forty-one client-owned dogs with GDV. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Blood was collected before surgery (baseline), postsurgery, 6-10 hours postsurgery, and 18-22 hours postsurgery. CRP and HMGB1 were measured in all samples, and routine hematological, biochemical, and acid-base analyses were performed. Only baseline and postsurgery samples were used from nonsurvivors (n = 10). CRP increased significantly from postsurgery sampling to 18-22 hours postsurgery, while HMGB1 did not change over time. There was a significant difference in HMGB1 between survivors and nonsurvivors over time. Both proteins correlated with systemic inflammatory response syndrome severity, total leukocyte, segmented neutrophils, and band counts. HMGB1 correlated also with acid-base parameters (pH, bicarbonate, base excess). CONCLUSION: HMGB1 and CRP behaved differently in regards to their kinetic patterns, with HMGB1 appearing to better reflect the severity of tissue injury in dogs with GDV than CRP.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26088834/