Peer-reviewed veterinary case report
C-Type Lectins in Veterinary Species: Recent Advancements and Applications.
- Journal:
- International journal of molecular sciences
- Year:
- 2020
- Authors:
- Lindenwald, Dimitri Leonid & Lepenies, Bernd
- Affiliation:
- University for Veterinary Medicine Hannover · Germany
- Species:
- rodent
Plain-English summary
C-type lectins (CTLs) are special proteins that help animals' immune systems recognize and fight off germs. They are important for keeping the body healthy and responding to infections. While most research on CTLs has focused on humans and lab animals like mice, recent studies are starting to explore how these proteins work in pets and other animals. This review discusses the latest findings about CTLs in veterinary medicine and how they might be used to improve treatments for animals. Overall, the research suggests that understanding CTLs better could lead to new ways to help keep pets healthy.
Abstract
C-type lectins (CTLs), a superfamily of glycan-binding receptors, play a pivotal role in the host defense against pathogens and the maintenance of immune homeostasis of higher animals and humans. CTLs in innate immunity serve as pattern recognition receptors and often bind to glycan structures in damage- and pathogen-associated molecular patterns. While CTLs are found throughout the whole animal kingdom, their ligand specificities and downstream signaling have mainly been studied in humans and in model organisms such as mice. In this review, recent advancements in CTL research in veterinary species as well as potential applications of CTL targeting in veterinary medicine are outlined.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32698416/