Peer-reviewed veterinary case report
Puppy Labrador with vomiting and drinking a lot after calcipotriol
By Fan, T M et al.·Published in The Journal of small animal practice·1998·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Calcipotriol toxicity in a dog.
- Species:
- dog
Plain-English summary
A six-month-old Labrador retriever was brought to the vet after drinking a tube of a skin treatment containing calcipotriol, which led to severe symptoms like excessive urination, increased thirst, and vomiting blood. The dog developed high calcium levels, kidney issues, and heart problems, and tests showed serious damage to multiple organs. Despite 13 days of intensive care, the dog's condition did not improve, and it was ultimately euthanized due to ongoing vomiting and refusal to eat. The necropsy confirmed that the dog suffered from severe vitamin D toxicity.
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Abstract
A six-month-old Labrador retriever was presented for investigation of acute polyuria, polydipsia and haematemesis six hours following ingestion of a tube of the topical antipsoriatic vitamin D analogue, calcipotriol. Transient hypercalcaemia, azotaemia, proteinuria, thrombocytopenia and ventricular arrhythmias ensued. Abdominal ultrasonography and echocardiography revealed evidence of diffuse soft tissue mineralisation. Despite 13 days of intensive supportive care, the dog was euthanased due to continued haematemesis and anorexia. Necropsy confirmed mineralisation and necrosis of multiple organ systems consistent with vitamin D toxicity.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/9888112/