Peer-reviewed veterinary case report
Calcium and phosphate levels in dogs with new hypercortisolism
By Corsini, Andrea et al.·Published in Journal of veterinary internal medicine·2021·Department of Veterinary Medical Sciences, Italy·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism.
- Species:
- dog
Plain-English summary
A group of 23 dogs with hypercortisolism (a condition where the body produces too much cortisol) showed higher levels of phosphate in their blood compared to healthy dogs. These dogs also had increased levels of parathyroid hormone, which helps regulate calcium and phosphate levels. However, their vitamin D levels were lower than those in healthy dogs. This suggests that dogs with hypercortisolism may have issues with calcium and phosphate balance, which could lead to further health problems. Treatment options may focus on managing these imbalances to improve their overall health.
People also search for: dog hypercortisolism symptoms · high phosphate levels in dogs · treatment for dog adrenal disease
Abstract
BACKGROUND: Hypercortisolism affects calcium and phosphate metabolism in dogs; however, the exact mechanisms are not completely understood. OBJECTIVES: To evaluate circulating concentrations of whole parathormone (wPTH), 25-hydroxyvitamin D (25-(OH)D), calcitriol, and fibroblast growth factor-23 (FGF-23) in dogs with naturally occurring hypercortisolism (NOHC) and healthy dogs, and their association with calcium and phosphate homeostasis. ANIMALS: Twenty-three client-owned dogs with NOHC, and 12 client or staff-owned healthy dogs. METHODS: Prospective cross-sectional study. The circulating concentrations of total calcium, ionized calcium (iCa), phosphate, wPTH, 25-(OH)D, calcitriol and FGF-23, and the urinary fractional excretion of phosphate (FEP) and calcium (FECa) were compared between dogs with NOHC before treatment and healthy dogs. RESULTS: Dogs with NOHC had higher mean serum phosphate concentrations (4.81 mg/dL, SD ± 0.71 vs 3.86 mg/dL, SD ± 0.60; P < .001), median FECa (0.43%, range, 0.03-2.44 vs 0.15%, range, 0.06-0.35; P = .005), and median serum wPTH concentrations (54.6 pg/mL, range, 23.7-490 vs 24.6 pg/mL, range, 5.5-56.4; P = .003) as compared to the controls. Circulating concentrations of total calcium, iCa, and calcitriol and the FEP did not differ between groups, whereas the serum 25-(OH)D concentrations were lower in dogs with NOHC as compared to the controls (70.2 pg/mL, SD ± 42.3 vs 106.3 pg/mL, SD ± 35.3; P = .02). The dogs with NOHC had lower plasma FGF-23 concentrations than controls (316.6 pg/mL, range, 120.8-575.6 vs 448.7 pg/mL, range, 244.8-753; P = .03). CONCLUSIONS AND CLINICAL IMPORTANCE: Urine loss of calcium and hyperphosphatemia could contribute to the adrenal secondary hyperparathyroidism.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33991143/