Peer-reviewed veterinary case report
Calcium and phosphate changes linked to kidney disease
By Williams, T L et al.·Published in The Journal of small animal practice·2012·Department of Veterinary Clinical Sciences, United Kingdom·View original on PubMed →
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Original publication title: Calcium and phosphate homeostasis in hyperthyroid cats: associations with development of azotaemia and survival time.
- Species:
- cat
Plain-English summary
A group of hyperthyroid cats was studied to see how their calcium and phosphate levels affected kidney health and survival. The researchers found that after treating the hyperthyroidism, the cats' hormone and mineral levels returned to normal, and these changes did not predict kidney problems later on. However, a specific hormone called fibroblast growth factor-23 was linked to overall survival, suggesting it might help indicate how well a cat with hyperthyroidism could do. Overall, treating hyperthyroidism in these cats improved their health without worsening kidney issues.
People also search for: hyperthyroid cat treatment · cat kidney disease symptoms · fibroblast growth factor-23 in cats
Abstract
OBJECTIVES: To evaluate calcium and phosphate homeostasis in hyperthyroid cats and determine if plasma parathyroid hormone and fibroblast growth factor-23 are associated with the presence of -azotaemic chronic kidney disease and/or have prognostic significance. METHODS: Retrospective cohort study. Logistic regression analysis and Cox regression analysis were performed to identify if parathyroid hormone and fibroblast growth factor-23 were predictors of development of azotaemia following treatment and survival time, respectively. RESULTS: Two hundred and seven hyperthyroid cats were included. Elevated plasma parathyroid hormone concentrations, hyperphosphataemia, decreased plasma fibroblast growth factor-23 concentrations and hypocalcaemia were documented; however, all parameters returned to reference intervals following treatment of hyperthyroid cats without azotaemic chronic kidney disease. After adjustment for plasma creatinine concentration, baseline plasma parathyroid hormone and fibroblast growth factor-23 concentrations were not predictors of the development of azotaemia following treatment. Baseline plasma fibroblast growth factor-23 concentrations were associated with all-cause mortality; however, this association was not maintained after adjustment for packed cell volume. CLINICAL SIGNIFICANCE: Changes in plasma parathyroid hormone and fibroblast growth factor-23 concentrations which occur in hyperthyroid cats are not mediators of progression of chronic kidney disease; however, fibroblast growth factor-23 would appear to have some prognostic significance in hyperthyroidism.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22860883/