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Peer-reviewed veterinary case report

Calculating the predictive value of the orthogonal testing approach and its use in clinical decision-making.

Journal:
Journal of the American Veterinary Medical Association
Year:
2025
Authors:
Wicker, Samuel A & Freeman, Kathleen P
Affiliation:
Department of Biomedical and Diagnostic Sciences

Abstract

Understanding the predictive value of diagnostic testing is a key component of clinical decision-making. Just as the predictive value of a single diagnostic test can be calculated, these formulas can be used to estimate the predictive value of multiple test results. Three clinical examples are provided to demonstrate how an orthogonal testing approach affects confidence in a clinical diagnosis.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/40562367/