Peer-reviewed veterinary case report
Can liquorice extract protect dogs' colons from robenacoxib damage
By Szweda, M et al.·Published in Polish journal of veterinary sciences·2015·View original on PubMed →
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Original publication title: Can liquorice extract and herbal solution prevent colonic mucosa damage caused by robenacoxib in dogs?
- Species:
- dog
Plain-English summary
A group of 15 healthy beagle puppies were given a common pain medication called robenacoxib, and some also received a herbal solution with liquorice extract to see if it could protect their intestines from damage. After 21 days, the puppies that only received robenacoxib showed the most intestinal damage, while those that received the herbal solution had less severe damage. This suggests that adding liquorice extract may help reduce the harmful effects of robenacoxib on the colon.
People also search for: dog pain medication side effects · robenacoxib intestinal damage · liquorice extract for dogs · herbal remedies for dog pain
Abstract
UNLABELLED: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in animals, especially in dogs, to manage pain due to inflammatory disease. This study investigated whether plant drugs can prevent mucosal injury induced by robenacoxib. We used fifteen healthy beagle dogs (7 male and 8 female) aged 4 months, weighing 4.2-5.1 kg at the beginning of the study. Endoscopy and biopsy of the colon were performed before and on the 21 day treatment with robenacoxib (1), robenacoxib, herbal solution with liquorice extract (2), placebo - an empty capsule (3). There were 5 animals in each group. The greatest microscopic damage in the colon was observed in animals which received robenacoxib. Plant drug administration reduced the severity of lesions in the colon when administered with robenacoxib (ARI = - 0.15). CONCLUSION: concurrent administration of liquorice extract and plant solution with robenacoxib was associated with significant decreased severity of the robenacoxib-induced colonic mucosal lesions.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26812822/