Peer-reviewed veterinary case report
Can satellite glial cells be therapeutic targets for pain control?
- Journal:
- Neuron glia biology
- Year:
- 2010
- Authors:
- Jasmin, Luc et al.
- Affiliation:
- Department of Anatomy · United States
- Species:
- rodent
Abstract
Satellite glial cells (SGCs) undergo phenotypic changes and divide the following injury into a peripheral nerve. Nerve injury, also elicits an immune response and several antigen-presenting cells are found in close proximity to SGCs. Silencing SCG-specific molecules involved in intercellular transport (Connexin 43) or glutamate recycling (glutamine synthase) can dramatically alter nociceptive responses of normal and nerve-injured rats. Transducing SGCs with glutamic acid decarboxylase can produce analgesia in models of trigeminal pain. Taken together these data suggest that SGCs may play a role in the genesis or maintenance of pain and open a range of new possibilities for curing neuropathic pain.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20566001/