Peer-reviewed veterinary case report
Yorkshire Terrier with hormone tumor causing Cushing's disease
By Baek, Yeong-Bin et al.·Published in The Journal of veterinary medical science·2019·College of Veterinary Medicine, South Korea·View original on PubMed →
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Original publication title: Canine adrenocorticotropic hormone-producing sinusoidal neuroendocrine tumor associated with Cushing's disease.
- Species:
- dog
Plain-English summary
An 18-year-old male Yorkshire Terrier was brought in with neurological issues, including weakness and a dull demeanor. The dog also had hair loss and a swollen belly. Tests revealed a tumor in the frontal sinus and brain, along with signs of Cushing's disease, which is caused by excessive cortisol production. Unfortunately, the dog had a serious tumor that was linked to these symptoms. Treatment options for such tumors can vary, so it's important to discuss potential therapies with your veterinarian.
People also search for: dog neurological signs · Yorkshire Terrier Cushing's disease · dog tumor treatment options
Abstract
An 18-year-old male Yorkshire Terrier was admitted with a history of neurological signs including dullness and progressive tetraparesis. Physical examination revealed bilaterally symmetrical alopecia and pot-bellied abdomen. Computed tomography and necropsy examination showed a mass across the frontal sinus and cerebral frontal lobe, bilateral adrenocortical hyperplasia, and hepatomegaly. Histopathologically, the tumor lesions consisted of sheets, nests, or cords of small- to medium-sized round-to-polyhedral cells. Adrenal cortex showed bilateral diffuse cellular proliferation, and some hepatocytes showed intracytoplasmic glycogen accumulation. Immunohistochemically, the tumor cells were positive for pancytokeratin, chromogranin-A, neuron-specific enolase, S100, synaptophysin, and thyroid transcription factor-1 but negative for microtubule-associated proein-2 and neurofilament, leading to the diagnosis of neuroendocrine tumor. These tumor cells were also positive for adrenocorticotropic hormone.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31656239/