Peer-reviewed veterinary case report
Ringworm from Microsporum gypseum in dogs and cats
By Nardoni, S et al.·Published in Journal de mycologie medicale·2013·Dipartimento di Scienze Veterinarie, Italy·View original on PubMed →
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Original publication title: Canine and feline dermatophytosis due to Microsporum gypseum: a retrospective study of clinical data and therapy outcome with griseofulvin.
Plain-English summary
A group of dogs and cats with skin infections caused by a fungus called Microsporum gypseum were treated with a medication called griseofulvin, often used for ringworm. Out of 41 dogs and 10 cats treated, about 39% of dogs and 40% of cats did not fully recover from their infections. The study found that the fungus was not very sensitive to griseofulvin, suggesting that this treatment might not be effective for these cases. Pet owners should discuss alternative treatment options with their veterinarian if their pet has a ringworm infection.
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Abstract
OBJECTIVE: Microsporum gypseum is a common inhabitant of the soil, occasionally responsible for human and animal ringworm. Few reports describe the treatment of dermatologic diseases due to M. gypseum. The objective of this study was to evaluate retrospectively cases of M. gypseum infection in dogs and cats. MATERIAL AND METHODS: The occurrence of infection by this dermatophyte was retrospectively evaluated in dermatological specimens from 15,684 dogs and cats dermatologically diseased from Italy. Clinical outcome after treatment with griseofulvin combined with topical enilconazole was evaluated in 41 dogs and, out of label, 10 cats. Furthermore, in vitro susceptibility to griseofulvin and enilconazole was evaluated on 31 clinical isolates of M. gypseum. RESULTS: One hundred and eighty-five specimens out of 15,684 (1.1%) scored positive for M. gypseum. The treatment failed to achieve both mycological and clinical cure in 16 dogs (39%) and four cats (40%), as well as fungal isolates demonstrated a very poor in vitro sensitivity when tested versus griseofulvin: the MIC value was 150 μg/mL. The ED50 value was calculated at 66 μg/mL. CONCLUSION: Blind treatments with griseofulvin in ringworm due to M. gypseum should be avoided.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23827239/