Peer-reviewed veterinary case report
Dog breeds at higher risk for atopic dermatitis in Australia
By Mazrier, Hamutal et al.·Published in Veterinary Dermatology·2016·Faculty of Veterinary Science B19 The University of Sydney Sydney NSW 2006 Australia, Australia·View original on Crossref →
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Original publication title: Canine atopic dermatitis: breed risk in Australia and evidence for a susceptible clade
- Species:
- dog
Plain-English summary
A study looked at 23,000 dogs treated at a veterinary hospital in Australia and found that certain breeds are more likely to develop atopic dermatitis (a skin allergy). Breeds such as boxers, bulldogs, Labrador retrievers, pugs, and West Highland white terriers showed a higher risk of this condition. Male pugs were particularly at risk. Understanding which breeds are more susceptible can help veterinarians diagnose and treat atopic dermatitis more effectively.
People also search for: dog skin allergies breeds · pug atopic dermatitis treatment · Labrador retriever skin problems
Abstract
BackgroundGenetic studies on canine atopic dermatitis (CAD) indicate that large populations from one geographical location are preferred for the identification of relevant susceptibility genes. Australian dogs are relatively isolated; studies onCADin this population are limited.Hypothesis/ObjectivesTo identify breeds at risk in the Australian dog population and to compare with worldwide breed predisposition.AnimalsCase records (n = 23,000) from University Veterinary Teaching Hospital (UVTH) dogs, including 722 withCAD.MethodsThe breed proportion ofCADand odds risk (OR) were calculated. A systematic review of 13 previous studies (1971–2010) was performed and compared to the study results by implementing an atopic dermatitis (AD)‐to‐reference population ratio (ADRPR).ResultsEleven dog breeds with significant increasedOR(≥1.0) were identified; all with breedCADcases proportionally higher than their base hospital population. Gender risk in males from the pug dog breed (P = 0.007) was detected and the bichon frise breed had a similar trend (P = 0.05). Sixteen predisposed dog breeds were identified by systematic review. All breeds with significant increasedORinUVTHhadADRPR > 1.4; five (boxer, bulldog, Labrador retriever, pug, West Highland white terrier) were recognized as predisposed worldwide. One clade of breeds with common ancestry was highly represented inCADcases worldwide and in Australia (81% of the significantORcases).Conclusion and clinical importanceThe use of a large population from one geographical location andADRPRprovided an objective comparison between worldwideADstudies; it identified one common clade of susceptible breeds. Breed genetics and related clinical presentation may helpCADdiagnosis and treatment.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/vde.12317