Peer-reviewed veterinary case report
Vaccinating African wild dog pups against distemper and parvovirus
By Mulreany, Lauren M et al.·Published in Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians·2021·University of Tennessee College of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: CANINE DISTEMPER AND PARVOVIRUS VACCINATION WITH RECOMBITEK C3 IN AFRICAN WILD DOGS ().
- Species:
- dog
Plain-English summary
A group of ten African wild dog puppies were vaccinated against canine distemper virus (CDV) and parvovirus using a vaccine called Recombitek C3. The puppies received the vaccine at 8, 12, and 16 weeks of age, and all showed a positive response to the distemper virus after the second vaccination. However, the levels of protection against parvovirus dropped significantly over time, with only half of the puppies having measurable protection by the end of the study. Overall, the vaccination was safe and effective in providing a strong response to the distemper virus in these wild dogs.
People also search for: African wild dog vaccination · canine distemper vaccine for dogs · parvovirus vaccine effectiveness in puppies
Abstract
Infectious disease threats are increasingly recognized as a major contributor to mortality in wild populations of African wild dog (AWD). Canine distemper virus (CDV) infection has been implicated as a cause of pack mortality in both captive and wild AWD populations. Ten animals were vaccinated with RecombitekC3, a vaccine containing a recombinant CDV, and modified live canine parvovirus (CPV) and adenovirus-2 components, at 8, 12, and 16 wk of age. Half of the pups received the vaccine IM and the other half SC. All ten pups had a positive serological response to CDV after the second vaccination, which decreased or stagnated after the third vaccination. Half of the pups had CDV titers ≥32 at 20 wk of age. Titers to CPV were high in all pups prior to vaccination and dropped precipitously over the course of the vaccine series. At the last sampling period, only 50% of the pups had measurable CPV titers. An initially higher titer was seen for CDV in the IM administration group; however, this was not significant at later time points. Vaccination with Recombitek C3 appears to be safe and effected a sustained serological response to CDV in AWD.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34998293/