Peer-reviewed veterinary case report
Eosinophilic lung nodules in a young Great Pyrenees dog
By Abbott, Dawn E E & Allen, Andrew L·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2020·Department of Veterinary Pathology, Canada·View original on PubMed →
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Original publication title: Canine eosinophilic pulmonary granulomatosis: case report and literature review.
- Species:
- dog
Plain-English summary
A 16-month-old male Great Pyrenees mix was brought to the vet with breathing problems. After imaging and tests, the dog was diagnosed with eosinophilic pulmonary granulomatosis (EPG), a condition where nodules form in the lungs due to an abnormal immune response. This condition is more common in younger dogs and can cause serious respiratory issues. Unfortunately, the case did not provide information on treatment or outcome, but EPG can be serious and requires veterinary attention.
People also search for: dog breathing problems · Great Pyrenees lung disease · eosinophilic pulmonary granulomatosis treatment
Abstract
We describe and illustrate herein a case of eosinophilic pulmonary granulomatosis (EPG) in a 16-mo-old, castrated male, Great Pyrenees crossbred dog. EPG appears to differ from eosinophilic pneumonias and eosinophilic bronchopneumopathy in dogs by the presence of nodules and masses in the lungs composed of eosinophils, macrophages, and various combinations of lymphocytes, plasma cells, neutrophils, and mast cells within fibrous tissue. Specific information from this dog was added to the information from the limited number of other dogs diagnosed with EPG reported in the veterinary literature, and the information analyzed. EPG appears to have no breed or sex predilection and tends to be a disease of younger dogs, often ≤ 3 y of age. Antemortem imaging of nodules and masses in the lungs, combined with cytologic evidence of eosinophils in the lesions, is highly suggestive of EPG, and the diagnosis can be confirmed postmortem. Concurrent eosinophilia and basophilia can be features of EPG, but their diagnostic value requires further investigation, as does the possible causal association withinfection.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32180541/