Peer-reviewed veterinary case report
What causes infectious respiratory disease in dogs and how it spreads
By Maboni, Grazieli et al.·Published in PloS one·2019·University of Georgia, United States·View original on PubMed →
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Original publication title: Canine infectious respiratory disease: New insights into the etiology and epidemiology of associated pathogens.
- Species:
- dog
Plain-English summary
A group of dogs with respiratory issues was studied to understand the causes of canine infectious respiratory disease (CIRD), which can involve multiple viruses and bacteria. The research found that while common pathogens like Bordetella bronchiseptica were less frequent, emerging bacteria such as Mycoplasma canis and Mycoplasma cynos might play a significant role. The study also highlighted that dogs with co-infections tended to show more severe symptoms, and factors like age were important in predicting how sick a dog might get. This information can help veterinarians better diagnose and treat dogs suffering from respiratory illnesses.
People also search for: dog coughing treatment · canine infectious respiratory disease symptoms · Mycoplasma in dogs
Abstract
Canine infectious respiratory disease (CIRD) is a syndrome where multiple viral and bacterial pathogens are involved sequentially or synergistically to cause illness. There is limited information regarding the prevalence of pathogens related to CIRD in the United States as well as the role of co-infections in the pathogenesis of the syndrome. We aimed to conduct a comprehensive etiologic and epidemiologic study of multiple CIRD agents in a diverse dog population using molecular methods and statistical modeling analyses. In addition, a novel probe-based multiplex real-time PCR was developed to simultaneously detect and differentiate two species of Mycoplasma (M. canis and M. cynos). Canine adenovirus, canine distemper virus, canine parainfluenza virus, coronavirus, influenza A virus (H3N2 and H3N8), Bordetella bronchiseptica, M. canis, M. cynos and Streptococcus equi subsp. zooepidemicus were investigated in specimens from clinically ill and asymptomatic dogs received at the Athens Veterinary Diagnostic Laboratory. Results showed low occurrence of classical CIRD agents such as B. bronchiseptica, canine adenovirus and distemper virus, while highlighting the potential role of emerging bacteria such as M. canis and M. cynos. Statistical modeling analyses of CIRD pathogens emphasized the impact of co-infections on the severity of clinical presentation, and showed that host factors, such as animal age, are the most important predictors of disease severity. This study provides new insights into the current understanding of the prevalence and role of co-infections with selected viruses and bacteria in the etiology of CIRD, while underscoring the importance of molecular diagnosis and vaccination against this disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31022218/