Peer-reviewed veterinary case report
Intranasal vaccine effects on kennel cough virus shedding in dogs
By Kontor, E. J. et al.·Published in American Journal of Veterinary Research·1981·From the Burns-Biotec Laboratories, Omaha, NE 68103.·View original on Crossref →
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Original publication title: Canine Infectious Tracheobronchitis: Effects of an Intranasal Live Canine Parainfluenza-Bordetella bronchiseptica Vaccine on Viral Shedding and Clinical Tracheobronchitis (Kennel Cough)
- Species:
- dog
Plain-English summary
A group of dogs was tested to see how well a new intranasal vaccine for kennel cough (canine infectious tracheobronchitis) worked compared to a traditional shot. The intranasal vaccine significantly reduced the chances of dogs showing symptoms of kennel cough by 96% and also lowered the amount of virus they shed after exposure. In contrast, dogs that received the traditional shot still showed symptoms and shed the virus more frequently. Overall, the intranasal vaccine proved to be much more effective in preventing kennel cough and reducing virus spread among dogs.
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Abstract
SUMMARY A modified-live intranasal (in) canine parainfluenza (cpi)-virus Bordetella bronchiseptica vaccine was evaluated in dogs for efficacy against laboratory-induced canine infectious tracheobronchitis. The comparative efficacies of in and parenteral administrations of the cpi virus fraction were also evaluated. The frequency and duration of clinical tracheobronchitis, blood serum agglutination titer, humoral antibody response, and duration of cpi virus and B bronchiseptica shedding were measured. Group A dogs were vaccinated subcutaneously or im with an experimental cpi vaccine and challenge exposed with cpi virus. Group B dogs were vaccinated in with avirulent cpi virus-B bronchiseptica live antigens and challenge exposed with virulent cpi virus and virulent B bronchiseptica. The in vaccination (group B) significantly reduced (P ≤ 0.001) the occurrence of clinical tracheobronchitis by 96%. The combined challenge exposure of virulent cpi and virulent B bronchiseptica produced a synergistic enhancement of the clinical signs of kennel cough. The percentage of days after challenge exposure that virus shedding was detected for controls equaled 70% as compared with 50% and only 1% for parenterally and in vaccinated dogs, respectively. Isolation of virulent B bronchiseptica microorganisms was reduced 89% in dogs vaccinated in compared with controls. The geometric mean humoral antibody titers to cpi virus after 2 parenteral vaccinations and 1 in vaccination were 1:43 and 1:34, respectively.
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Search related cases →Original publication on Crossref: https://doi.org/10.2460/ajvr.1981.42.10.1694