Peer-reviewed veterinary case report
Outcomes of inflammatory bowel disease in 80 dogs treated 1995-2002
By Craven, M et al.·Published in The Journal of small animal practice·2004·University of Edinburgh, United Kingdom·View original on PubMed →
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Original publication title: Canine inflammatory bowel disease: retrospective analysis of diagnosis and outcome in 80 cases (1995-2002).
- Species:
- dog
Plain-English summary
A group of 80 dogs diagnosed with inflammatory bowel disease (IBD) showed various symptoms like vomiting, diarrhea, and weight loss. The most common treatments included medications like prednisolone and metronidazole. After follow-up, about 26% of the dogs were in remission for an average of 14 months, while half experienced ongoing symptoms. Unfortunately, some dogs had to be euthanized due to severe cases that did not respond to treatment. The study found that low protein levels at diagnosis were linked to poorer outcomes, but dietary changes did not seem to help.
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Abstract
The case records of 80 dogs in which idiopathic inflammatory bowel disease (IBD) had been diagnosed were reviewed, and owners were contacted for follow-up information using a telephone questionnaire. The types of IBD encountered were lymphocytic (n=6), lymphocytic-plasmacytic (n=38), eosinophilic (n=6) and mixed inflammation (n=30). Prednisolone, sulphasalazine, metronidazole and tylosin were the most frequently prescribed medications. At follow-up, 21 dogs (26 per cent) were classified as being in remission (for a median of 14 months), 40 dogs (50 per cent) had intermittent clinical signs (for a median of 17 months) and three dogs (4 per cent) had uncontrolled disease (for a median of 19 months). Ten dogs (13 per cent) had been euthanased due to refractory IBD and four of these had entered remission for a median of 21 months prior to developing severe relapse and refractoriness to further treatment. Six dogs (8 per cent) had been euthanased or had died for reasons unrelated to IBD. Hypoalbuminaemia at the time of diagnosis was significantly associated with a negative outcome (P=0.0007). No association was found between the site (P=0.75), type (P=0.44) and severity (P=0.75) of disease. Dietary change to single protein and carbohydrate commercial diets had no association with outcome (P=0.12). Owner assessment of quality of life at follow-up was significantly associated with outcome (P=0.006).
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15266855/