Peer-reviewed veterinary case report
Dog intestinal mast cell tumor with c-kit mutation shrinks
By Kobayashi, Masato et al.·Published in Veterinary journal (London, England : 1997)·2012·Department of Veterinary Clinical Pathology, Japan·View original on PubMed →
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Original publication title: Canine intestinal mast cell tumor with c-kit exon 8 mutation responsive to imatinib therapy.
- Species:
- dog
Plain-English summary
A dog with an intestinal mast cell tumor that had spread to the spleen was treated with a medication called imatinib. After starting treatment, the size of both the intestinal tumor and the metastasis significantly decreased, although the improvement didn't last long. Tests revealed a specific mutation in the tumor cells that made the cancer more aggressive, but imatinib was able to block the effects of this mutation. While the response to treatment was temporary, it showed that imatinib could help manage this type of tumor in dogs.
People also search for: dog intestinal tumor treatment · mast cell tumor in dogs · imatinib for dog cancer
Abstract
A canine intestinal mast cell tumor with splenic metastasis was treated with imatinib. The intestinal and metastatic tumor masses markedly decreased following treatment although the clinical response was short lasting. A c-kit internal tandem duplication mutation, c.1250_1261dup, which causes an insertion of four amino acids in KIT, was identified in cDNA isolated from the tumor cells. The phosphorylation status of the mutant KIT and the effect of imatinib on its phosphorylation were examined using 293 cells transfected with c-kit carrying the c.1250_1261dup mutation. This mutation caused ligand-independent phosphorylation of KIT, which was suppressed by imatinib. Inhibition of constitutively activated mutant KIT with imatinib could underlie the tumor response in this dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22153896/