Peer-reviewed veterinary case report
Canine invasive lobular carcinoma of the mammary gland: morphological and immunohistochemical characterizations of three cases.
- Journal:
- Journal of comparative pathology
- Year:
- 2011
- Authors:
- Ressel, L et al.
- Affiliation:
- Department of Animal Pathology · Italy
- Species:
- dog
Abstract
Invasive lobular carcinoma (ILC) represents 15% of invasive human breast tumours. This report describes the morphological and immunohistochemical features of three canine mammary tumours comparable with human ILC. These tumours were composed of a non-delimited proliferation of discrete cells infiltrating fibrous connective tissue. Multifocal in-situ carcinoma associated with invasive lesions was present. Invasive tumour cells and in-situ lesions expressed cytokeratin and CK34betaE12, but not E-cadherin. Based on these morphological and immunohistochemical characteristics, the tumours were classified as canine ILC.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20961557/