Peer-reviewed veterinary case report
Leucocyte adhesion deficiency found in Irish red and white setters
By Debenham, S L et al.·Published in The Journal of small animal practice·2002·Animal Health Trust·View original on PubMed →
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Original publication title: Canine leucocyte adhesion deficiency in Irish red and white setters.
- Species:
- dog
Plain-English summary
A group of Irish red and white setters was tested for a genetic mutation linked to a serious condition called canine leucocyte adhesion deficiency (CLAD), which can lead to immune system problems and increased risk of infections. Six dogs were found to be carriers of this mutation, which had previously caused sporadic deaths in some dogs from this breed. This finding shows that the mutation is present in a notable number of Irish red and white setters, not just Irish setters. Breeders can now test for this mutation to help prevent CLAD in future generations of these dogs.
People also search for: Irish red and white setter health issues · canine leucocyte adhesion deficiency symptoms · genetic testing for dog breeds
Abstract
Seventy-six Irish red and white setter samples were tested for the recently documented CD18 point mutation which manifests as canine leucocyte adhesion deficiency (CLAD) in Irish setters. Six carrier dogs were identified, all originating from a lineage within which sporadic deaths from symptoms consistent with CLAD had been observed. This is the first demonstration that the CLAD mutation exists outside the Irish setter population, confirming that the mutation is present in a significant minority of Irish red and white setters. Routine testing by breeders to identify carrier animals will enable the eradication of CLAD from the Irish red and white setter population.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/11873952/