Peer-reviewed veterinary case report
Canine lymphoma cases and traits at a referral hospital
By Sánchez, Diana et al.·Published in Veterinaria México OA·2019·View original on Crossref →
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Original publication title: Canine lymphoma: Pathological and clinical characteristics of patients treated at a referral hospital
- Species:
- dog
Plain-English summary
A group of dogs diagnosed with lymphoma, a type of cancer, were treated at a veterinary hospital over a year. Most of the affected dogs were Miniature Schnauzers, with an average age of 7.5 years. The majority had advanced stages of the disease and were treated with chemotherapy, which worked for about 73% of them, leading to an average survival time of about 219 days. One dog with skin lymphoma responded well to a different treatment and was still doing well after 548 days. This highlights the need for earlier diagnosis and better treatment options for dogs with lymphoma.
People also search for: dog lymphoma treatment · Miniature Schnauzer cancer symptoms · chemotherapy for dogs with lymphoma
Abstract
Non-Hodgkin’s lymphomas are common canine cancers with variable demographic and clinical presentations. Their pathological characterization and treatment lag far behind those of humans. We describe consecutive lymphoma patients detected over a one-year period at the National Autonomous University of Mexico (UNAM). Of 4,512 dogs: 220 (4.9%) had a cancer diagnosis, of which 27 (0.6%) had lymphoma (12% of cancer patients). We found an association with Miniature Schnauzers, which represented 18.5% (5/27) of lymphoma patients, but it was only 6.4% (288/4,512) of the dogs studied in this time period (p < 0.011). Miniature Schnauzers and mongrels together constituted nearly half of lymphoma cases. Mean age at diagnosis was 7.5 years (3-14), with a female to male ratio of 1.7:1. We found no correlation between lymphoma and castration status. Most patients presented nodal involvement (80%), were in advanced stages III/IV (90%) and had B-cell versus T-cell tumors (64%/36%). Only two histopathological patterns were seen, both with diffuse nodal-replacement by large immunoblast and/or centroblast-like cells; one having numerous tingible-body macrophages which are suggestive of a high proliferative rate. Chemotherapy was given to 15 patients (65%) with an overall response of 73% (3 complete responses/8 partial responses) and a mean overall survival of 219 days (4-586; SD±185). One cutaneous lymphoma-patient achieved partial response (PR) with lomustine/prednisone, and treatment was still ongoing at 548 days. Earlier diagnosis, better lymphoma subtype distinction, and specific curative treatments are needed.
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Search related cases →Original publication on Crossref: https://doi.org/10.22201/fmvz.24486760e.2019.2.495