Peer-reviewed veterinary case report
Puppies with distemper virus and multiple infections found in tissue
By Headley, Selwyn A et al.·Published in Scientific reports·2018·Department of Veterinary Preventive Medicine, Brazil·View original on PubMed →
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Original publication title: Canine morbillivirus (canine distemper virus) with concomitant canine adenovirus, canine parvovirus-2, and Neospora caninum in puppies: a retrospective immunohistochemical study.
- Species:
- dog
Plain-English summary
Fifteen puppies that died suddenly were found to have multiple infections, including canine distemper virus (CDV), which is known to cause severe illness. The puppies showed various symptoms, such as intestinal damage, liver issues, and respiratory problems. Testing revealed that all puppies had CDV, and many also had infections from other viruses and parasites. Unfortunately, despite the findings, there was no effective treatment reported, and the puppies did not survive. This highlights the importance of vaccinations and early veterinary care to prevent such serious infections in puppies.
People also search for: puppy sudden death causes · canine distemper virus symptoms · puppy vaccination importance · canine parvovirus treatment · puppy respiratory problems
Abstract
A retrospective immunohistochemical study was designed to investigate the frequency of concomitant traditional infectious disease pathogens in puppies that died suddenly and review the aspects of associated pathogenesis. Fifteen puppies were evaluated; the pathology reports and histopathologic slides of these animals were reviewed to determine the pattern of histopathologic lesions. The intralesional identification of antigens of canine (distemper) morbillivirus (CDV), canine adenovirus-1 and -2 (CAdV-1 and -2), canine parvovirus-2 (CPV-2), Toxoplasma gondii, and Neospora caninum was evaluated by IHC within the histopathologic patterns observed. All puppies contained CDV nucleic acid by molecular testing. The most frequent histopathologic patterns were intestinal crypt necrosis (n = 8), white matter cerebellar demyelination (n = 7), necrohaemorrhagic hepatitis (n = 7), interstitial pneumonia (n = 7), and gallbladder oedema (n = 5). All puppies contained intralesional antigens of CDV in multiple tissues resulting in singular (n = 3), and concomitant dual (n = 3), triple (n = 5) and quadruple (n = 4) infections by CAdV-1, and -2, CPV-2, and N. caninum; T. gondii was not identified. Concomitant infections by CDV was observed with N. caninum (100%; 1/1), CPV-2 (100%; 8/8), CAdV-1 (100%; 8/8), and CAdV-2 (100%; 8/8). Intralesional antigens of CDV and not CAdV-1 were identified in cases of gallbladder oedema. The "blue eye" phenomenon was histologically characterized by corneal oedema and degenerative lesions to the corneal epithelium, without inflammatory reactions.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30194440/