Peer-reviewed veterinary case report
Common skin biopsy features in dogs with noninflammatory hair loss
By Müntener, Tabitha et al.·Published in Veterinary dermatology·2012·Institute of Animal Pathology·View original on PubMed →
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Original publication title: Canine noninflammatory alopecia: a comprehensive evaluation of common and distinguishing histological characteristics.
- Species:
- dog
Plain-English summary
A group of dogs with various types of hair loss, including alopecia X, were studied to understand the underlying causes of their condition. The researchers found that these dogs had a significant increase in hair follicles that were not producing hair, indicating a problem with the hair growth cycle. Specifically, dogs with alopecia X had fewer active hair follicles and more resting ones, suggesting that their hair growth was disrupted. While the exact cause of these hair loss disorders remains unclear, the study highlights the need for further research to better understand how to treat these conditions effectively.
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Abstract
BACKGROUND: Noninflammatory alopecia is a frequent problem in dogs, and the pathogenesis is still unclear. OBJECTIVE: The objective of this study was a comparative histological description of skin biopsies from dogs with different alopecic disorders and control dogs matched for coat type, season and disease duration. ANIMALS: Twenty-one cases of alopecia X in plush-coated dogs, 12 cases of recurrent flank alopecia, three cases of hyperestrogenism, 15 cases of hyperadrenocorticism, 12 cases of hypothyroidism and 12 cases of primary alopecic disorders of unknown cause were evaluated. The controls were biopsies from 38 dogs of different coat types. METHODS: We evaluated five serial sections of each biopsy histologically and immunohistologically to compare the histological findings within the disease groups and with the control. RESULTS: All the dogs with hair cycle disorders had a significant increase in the number of hairless hair follicles, which we assigned to kenogen. In addition, dogs with alopecia X had the lowest percentage of anagen follicles and the highest percentage of telogen follicles. CONCLUSIONS: The marked increase in kenogen follicles is a strong indication that the induction of the new anagen phase is impaired in hair cycle disorders. The findings in dogs with alopecia X further suggest that premature catagen is also involved in the pathogenesis. Further work to investigate the stem cell compartment and possible initiating factors for the different cycle phases is required to elucidate the exact pathogenesis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22575019/