Peer-reviewed veterinary case report
Pancreatic enzyme levels linked to disc disease in 84 dogs
By Schueler, R O et al.·Published in The Journal of small animal practice·2018·Veterinary Neurology and Rehabilitation Center, United States·View original on PubMed →
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Original publication title: Canine pancreatic lipase immunoreactivity concentrations associated with intervertebral disc disease in 84 dogs.
- Species:
- dog
Plain-English summary
A group of 84 dogs with intervertebral disc disease (a condition where the discs in the spine become damaged) had their blood tested for a specific enzyme called pancreatic lipase. The results showed that dogs with this spinal issue had higher levels of this enzyme compared to healthy dogs. In a follow-up, many of the dogs with elevated enzyme levels showed improvement in their symptoms after a few weeks. This suggests that monitoring pancreatic lipase levels could help veterinarians understand and manage intervertebral disc disease in dogs better.
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Abstract
OBJECTIVE: To determine the differences in serum canine pancreatic lipase immunoreactivity between dogs with intervertebral disc herniation and healthy control dogs. MATERIALS AND METHODS: Eighty-four client-owned dogs with intervertebral disc herniation, diagnosed by neurologic examination and imaging, and 18 healthy control dogs. Samples of whole blood were collected within 90 minutes of admission. Serum canine pancreatic lipase immunoreactivity concentrations were measured by a commercial immunoassay and evaluated for association with intervertebral disc herniation, signalment, neurolocalisation and the preadmission administration of glucocorticosteriods or non-steroidal anti-inflammatory drugs. RESULTS: Serum canine pancreatic lipase immunoreactivity concentrations were statistically increased in dogs with intervertebral disc herniation (P<0·01, n=38). A subgroup of dogs (19/38) with elevated canine pancreatic lipase immunoreactivity concentrations was re-evaluated between 2 and 4 weeks later, and 15 had resolution of clinical signs and values less than 200 μg/L. Serum canine pancreatic lipase immunoreactivity concentrations were not significantly correlated with clinical gastrointestinal disease, neurolocalisation or the preadmission administration of corticosteroids or non-steroidal anti-inflammatory drugs. CLINICAL SIGNIFICANCE: These results suggest that serum canine pancreatic lipase immunoreactivity concentrations are significantly elevated in dogs with intervertebral disc herniation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29355958/