Peer-reviewed veterinary case report
Pancreatic enzyme levels in dogs with heart valve failure
By Han, D et al.·Published in Journal of veterinary internal medicine·2015·College of Veterinary Medicine, South Korea·View original on PubMed →
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Original publication title: Canine pancreatic-specific lipase concentrations in dogs with heart failure and chronic mitral valvular insufficiency.
- Species:
- dog
Plain-English summary
A group of dogs with chronic mitral valvular insufficiency (CMVI), a common heart condition, were tested for pancreatic injury by measuring a specific enzyme in their blood. The results showed that as the severity of heart failure increased, so did the levels of this enzyme, indicating potential pancreatitis (inflammation of the pancreas). This suggests that dogs with heart failure may also be at risk for pancreatic problems. Regular monitoring of this enzyme could help veterinarians keep an eye on the health of dogs suffering from heart failure.
People also search for: dog heart failure symptoms · pancreatitis in dogs treatment · chronic mitral valve disease in dogs
Abstract
BACKGROUND: Chronic mitral valvular insufficiency (CMVI) in dogs is very common and might cause clinical signs of congestion and poor tissue perfusion. HYPOTHESIS: Poor tissue perfusion from CMVI causes pancreatitis in dogs, as indicated by serum pancreatic lipase concentrations. ANIMALS: Sixty-two client-owned dogs consisting of 40 dogs with different stages of heart failure from CMVI and 22 age-matched healthy dogs, based on full cardiac exam and routine laboratory tests. METHODS: Prospective, controlled, observational study. Serum canine pancreatic lipase immunoreactivity (cPLI) concentrations were determined by quantitative cPLI test in healthy and CMVI groups. RESULTS: Serum cPLI concentrations were 54.0 μg/L (IQR: 38.0-78.8 μg/L) in control, 55.0 μg/L (IQR: 38.3-88.8 μg/L) in ISACHC I, 115.0 μg/L (IQR: 45.0-179.0 μg/L) in ISACHC II and 223.0 μg/L (IQR: 119.5-817.5 μg/L) in ISACHC III. Close correlation to serum cPLI concentration was found in the left atrial to aorta (LA/Ao) ratio (r = 0.597; P = .000) and the severity of heart failure (r = 0.530; P = .000). CONCLUSIONS AND CLINICAL IMPORTANCE: This study found CMVI is associated with pancreatic injury in congestive heart failure caused by CMVI. Therefore, periodic monitoring on cPLI could be useful in monitoring dogs in heart failure.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25586363/