Peer-reviewed veterinary case report
Dog with papillomavirus type 16 linked to skin cancer findings
By Alves, Christian D B T et al.·Published in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]·2020·Laborató, Brazil·View original on PubMed →
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Original publication title: Canine papillomavirus type 16 associated to squamous cell carcinoma in a dog: virological and pathological findings.
- Species:
- dog
Plain-English summary
A mixed-breed female dog developed pigmented skin plaques that were later found to be caused by a virus known as canine papillomavirus type 16. Over time, these plaques progressed into squamous cell carcinoma, a type of skin cancer. The affected areas were mainly on her belly and the inside of her legs. After thorough testing, the presence of the virus was confirmed in the cancerous cells. Treatment options for this condition typically include surgical removal of the tumors, and early intervention can lead to better outcomes for affected dogs.
People also search for: dog skin cancer treatment · canine papillomavirus symptoms · dog pigmented plaques causes
Abstract
Papillomaviruses (PVs) are circular double-stranded DNA virus belonging to Papillomaviridae family. During the infection cycle, PVs translate proteins that can influence cell growth and differentiation, leading to epidermal hyperplasia and papillomas (warts) or malignant neoplasms. Canis familiaris papillomaviruses (CPVs) have been associated with different lesions, such as oral and cutaneous papillomatosis, pigmented plaques, and squamous cell carcinomas (SCCs). Here, we report a clinical case of a mixed bred female dog with pigmented plaques induced by CPV16 (Chipapillomavirus 2) that progressed to in situ and invasive SCCs. Gross and histological findings were characterized, and the lesions were mainly observed in ventral abdominal region and medial face of the limbs. In situ hybridization (ISH) revealed strong nuclear hybridization signals in the neoplastic epithelial cells, as well as in the keratinocytes and koilocytes of the pigmented viral plaques. The full genome of the CPV16 recovered directly from the lesions was characterized, and the phylogenetic relationships were determined. The identification of oncoprotein genes (E5, E6, and E7) by high throughput sequencing (HTS) and their expected domains are suggestive of the malignant transformation by CPV16.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32494977/