Peer-reviewed veterinary case report
Bone marrow damage in puppy with parvovirus infection and symptoms
By K. Nagarajan, Professor·Published in Indian Journal of Veterinary Pathology·2026·View original on Crossref →
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Original publication title: Canine Parvovirus-2a infection in a juvenile pup: Bone marrow findings and clinical implications
- Species:
- dog
Plain-English summary
A 2-month-old puppy was brought to the emergency vet with a 4-day history of bloody diarrhea, vomiting, and signs of neurological issues. Blood tests showed severe anemia and a low white blood cell count, indicating a weakened immune system. Unfortunately, the puppy had extensive damage to its intestines and other organs due to a parvovirus infection. The vet confirmed the diagnosis through tests and noted that examining the bone marrow was crucial for understanding the severity of the infection. Sadly, despite the findings, the outcome for the puppy was not positive due to the extent of the disease.
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Abstract
A 2 month old non descriptive pup was presented to the Emergency and Critical Care Unit (ECCU) at Madras VeterinaryCollege Teaching Hospital with a 4-day clinical history of bloody diarrhoea, vomition and neurological manifestations suggestive of severe systemic involvement. Haematological analysis revealed anaemia and profound leukopenia, indicative of markedimmunosuppression. Necropsy findings demonstrated extensive hemorrhagic enteritis and multi-organ pathology, includingfatty enlarged liver and epicardial pallor. Histopatholgical examination revealed hepatic fatty degeneration, myocardial fibre degeneration, and intestinal crypt cell necrosis.Bone marrow examination showed severe hypocellularity with depletion of myeloidand erythroid cell lines that lead to leukopenia. Molecular detection and characterization of the VP2 gene confirmed infectionwith the CPV-2a variant, genetically related to strains reported from India, Bangladesh, and Nigeria. The study highlights theimportance of bone marrow evaluation in diagnosing and managing CPV-2 infection, and underscores the value of integratingmolecular and pathological findings for accurate diagnosis and improved treatment outcomes.
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Search related cases →Original publication on Crossref: https://doi.org/10.56093/cr49qj17