Peer-reviewed veterinary case report
Canine parvovirus and chicken anemia genes partly shrink
By Bhat, Aubid Hussain et al.·Published in Scientific Reports·2017·View original on Crossref →
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Original publication title: Canine Parvovirus ns1 gene and Chicken Anemia vp3 gene induce partial oncolysis of Canine Transmissible Venereal Tumor
- Species:
- dog
Plain-English summary
A group of dogs with Canine Transmissible Venereal Tumor (CTVT) received treatments involving genes from Canine Parvovirus and Chicken Anemia to see if they could help shrink the tumors. Over three weeks, the dogs were given injections of these genes, either alone or in combination. While the treatments stopped the tumors from growing further, most dogs did not fully recover, indicating that the gene therapy was only partially effective. The best results came from the Canine Parvovirus gene, which showed the most promise as a potential treatment option for this type of tumor.
People also search for: dog tumor treatment · Canine Transmissible Venereal Tumor therapy · Canine Parvovirus gene therapy
Abstract
AbstractThe oncolytic effect of Canine Parvovirusns1gene and Chicken Anemiavp3gene in naturally occurring cases of Canine Transmissible Venereal Tumor (CTVT) is being reported. Dogs suffering from CTVT (N = 18) were systematically randomized into three groupsviz. A, B, and C (n = 6). Animals of the groups A, B, and C received 100 µg of thens1gene,vp3gene, andns1 + vp3gene combination, respectively, for three weeks intratumorally at weekly intervals; results were normalized against base values before commencement of therapy and after complete remission that were taken as negative and positive controls, respectively. Initiation of oncolytic gene therapy arrested the further progression of the tumor but most of the animals in the study underwent incomplete remission, indicating incomplete activity ofns1andvp3genes. The oncolytic effect of the treatments was in the orderns1 > vp3 > ns1 + vp3. Oncolysis was accompanied by decreased mitotic index and AgNOR count, and increased TUNEL positive cells and CD4+lymphocyte counts. Our findings show that Canine Parvovirusns1may eventually find an important role as an oncolytic agent.
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Search related cases →Original publication on Crossref: https://doi.org/10.1038/s41598-017-15734-6