Peer-reviewed veterinary case report
Serum amyloid A blood test detects inflammation in dogs
By Christensen, Michelle B et al.·Published in The Journal of veterinary medical science·2013·Department of Veterinary Clinical and Animal Sciences·View original on PubMed →
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Original publication title: Canine serum amyloid A (SAA) measured by automated latex agglutination turbidimetry is useful for routine sensitive and specific detection of systemic inflammation in a general clinical setting.
- Species:
- dog
Plain-English summary
A study found that measuring a protein called serum amyloid A (SAA) can help veterinarians detect systemic inflammation in dogs. Researchers tested this method on 247 dogs, comparing SAA levels in those with and without inflammation. They discovered that dogs with inflammation had much higher SAA levels, making it a reliable marker for diagnosing issues related to conditions like neurological disorders, cancer, and gastrointestinal problems. This automated test can be used in regular veterinary practices to quickly identify inflammation, helping vets make better treatment decisions for their patients.
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Abstract
Canine serum amyloid A (SAA) is a useful diagnostic marker of systemic inflammation. A latex agglutination turbidimetric immunoassay (LAT) was validated for automated measurements. The aim of the study was to evaluate the clinical applicability of SAA measured by the LAT. SAA was measured in 7 groups of dogs with and without systemic inflammation (n=247). Overlap performance was investigated. Diagnostic performance was compared to body temperature and leukocyte markers. Clinical decision limits for SAA were estimated. In dogs with neurological, neoplastic or gastrointestinal disorders (n=143), it was investigated whether a higher proportion of SAA positive dogs could be detected in cases of complications with risk of systemic inflammation. Significantly higher concentrations of SAA were measured in dogs with (range [48.75; 5,032 mg/l]), compared to dogs without systemic inflammation [0; 56.4 mg/l]. SAA was a more sensitive and specific marker of systemic inflammation (area under the receiver-operating characteristic curve (AUC) 1.00), compared to body temperature (0.6) and segmented neutrophils (best performing leukocyte marker, 0.84). A clinical decision limit of 56.4 mg/l was established giving close to perfect discrimination between dogs with and without systemic inflammation. Higher proportions of SAA-positive dogs were observed in dogs with neurological, neoplastic and gastrointestinal disorders with complications known to increase risk of systemic inflammation, compared to uncomplicated cases. The automated LAT makes SAA applicable as a relevant diagnostic marker of systemic inflammation in dogs for routine random-access real-time use in a general clinical setting.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23196800/