Peer-reviewed veterinary case report
High alkaline phosphatase in dog with liver cancer tumor
By Fukui, Yu-ichi et al.·Published in The Journal of veterinary medical science·2006·Department of Veterinary Medicine·View original on PubMed →
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Original publication title: Canine serum thermostable alkaline phosphatase isoenzyme from a dog with hepatocellular carcinoma.
- Species:
- dog
Plain-English summary
A 9-year-old male dog was diagnosed with liver cancer (hepatocellular carcinoma) after showing very high levels of a specific enzyme called alkaline phosphatase in his blood. Tests on fluid from his abdomen and tumor tissue revealed even higher enzyme levels, which were unusual. Researchers found that this enzyme had unique properties that were previously only seen in humans with similar tumors. This specific enzyme was not present in other dogs with different liver issues, suggesting it could be a marker for liver cancer in dogs. Unfortunately, the abstract does not mention treatment outcomes for this dog.
People also search for: dog liver cancer symptoms · high alkaline phosphatase in dogs · liver tumor treatment for dogs
Abstract
A dog histopathologically diagnosed with hepatocellular carcinoma (HCC) showed very high serum alkaline phosphatase (ALP) activity. A supernatant of ascitic fluid and tumor tissue extracted from the dog also showed much higher ALP activity than normal. ALP isoenzyme analysis of samples was performed using polyacrylamide gel disk electrophoresis, and a wide, broad abnormal band was observed. By various treatments, the abnormal band showed thermostability, which is a characteristic of tumor-associated ALP that has only been reported in humans. The thermostable ALP isoenzyme was not found in sera from 39 dogs with several types of tumor that originated from the liver, except for HCC, nor was it found in 10 dogs with hepatic diseases that did not include hepatic tumors. The thermostable ALP isoenzyme seemed to be associated with canine HCC.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17085898/