Peer-reviewed veterinary case report
Dog with sterile neutrophilic skin disease and severe organ problems
By Hammes, K et al.·Published in Schweizer Archiv fur Tierheilkunde·2019·Bessy's Kleintierklinik AG·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Canine sterile neutrophilic dermatosis (resembling Sweet's syndrome) with severe extracutaneous manifestations.
- Species:
- dog
Plain-English summary
A 2-year-old Bearded Collie was brought to the vet with a fever, weakness in the back legs, swollen lymph nodes, and abnormal blood test results over three weeks. Skin lesions developed later, and tests showed severe inflammation and issues with the kidneys and liver. The dog was diagnosed with a rare condition similar to Sweet's syndrome, which caused both skin and systemic symptoms. Treatment with dexamethasone and mycophenolate mofetil helped the dog recover, but after three months, the symptoms returned and were managed again with a short course of dexamethasone and an increased dose of mycophenolate mofetil.
People also search for: dog fever and weakness · Bearded Collie skin problems · treatment for dog neutrophilic dermatosis
Abstract
Sterile neutrophilic dermatosis is a rare disease in dogs, similar to Sweet's syndrome in humans. This case report describes the treatment of a 2-year old Bearded Collie that was presented with a 3-week history of fever, hind-limb weakness, peripheral lymphadenomegaly and leucocytosis. Blood tests revealed severe leukocytosis, renal azotaemia, elevated liver enzymes and bilirubinaemia. Skin lesions started to appear in week four. Histology revealed a sterile neutrophilic dermatitis resembling Sweet's syndrome. The dog displayed extracutaneous manifestations, including fever, polyarthritis, a severe leukemoid reaction, anaemia, hepatopathy and nephropathy. Issues regarding the use of criteria for the diagnosis of Sweet's syndrome in humans that are used for dogs with sterile neutrophilic dermatosis, are discussed in this case report. The condition resolved with dexamethasone and mycophenolate mofetil as a novel steroid-sparing therapy. Three months later the dog relapsed, which rapidly responded to short-term dexamethasone treatment and temporarily increased mycophenolate mofetil dosage.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30942190/