Peer-reviewed veterinary case report
Synovial myxoma tumors in large-breed dogs' knees and toes
By Craig, L E et al.·Published in Veterinary pathology·2010·Department of Pathobiology, United States·View original on PubMed →
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Original publication title: Canine synovial myxoma: 39 cases.
- Species:
- dog
Plain-English summary
A middle-aged Doberman Pinscher was diagnosed with a synovial myxoma, a type of tumor that formed gelatinous nodules in the joint. The tumor was found in the dog's stifle (knee) and caused swelling and discomfort. Even though some dogs experienced local recurrence after surgery, most had a good outcome and lived for an average of 2.5 years after treatment, even if the tumor was not completely removed. This type of tumor does not spread to other parts of the body, which is reassuring for pet owners.
People also search for: dog knee tumor treatment · Doberman Pinscher joint swelling · synovial myxoma prognosis
Abstract
This report describes the signalment, clinical findings, gross appearance, histological and immunohistochemical characteristics, and behavior of 39 cases of canine synovial myxoma. Large-breed middle-aged dogs-especially, Doberman Pinschers and Labrador Retrievers-were most commonly affected. The stifle and digit were the most common sites. Grossly, the tumors were composed of gelatinous nodules that often filled the joint cavity and exuded viscous fluid on cut section. In 12 cases (31%), radiographic bony lysis or grossly invasive growth was noted clinically. Histologically, the nodules were sparsely cellular and composed of stellate to spindle cells suspended in an abundant myxomatous matrix. By immunohistochemistry, the cells were positive for vimentin, heat shock protein 25, and cadherin 11 and negative for cytokeratin and S100 protein; some cells (20-40%) were positive for CD18. Affected dogs had long survival times (average, 2.5 years), even with incomplete excision of the tumor. Three cases had local recurrence, but none metastasized or directly resulted in death. Canine synovial myxoma is a histologically distinctive tumor with a good prognosis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20460449/