Peer-reviewed veterinary case report
Muscle weakness and pain in young Grand Basset Griffon Vendéen dogs
By Klarenbeek, S et al.·Published in Journal of comparative pathology·2007·Departments of Pathobiology. Electronic address: s.klarenbeek@vet.uu.nl.·View original on PubMed →
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Original publication title: Canine X-linked muscular dystrophy in a family of Grand Basset Griffon Vendéen dogs.
- Species:
- dog
Plain-English summary
Three related Grand Basset Griffon Vendéen puppies, two males and one female, showed signs of poor movement and muscle pain. Sadly, they were humanely euthanized at around 2 months old, and a thorough examination revealed they had canine X-linked muscular dystrophy (CXMD), a genetic condition that affects muscle function. The puppies' muscles showed significant damage and signs of regeneration, while their parents appeared healthy. This case is notable as it's the first reported instance of CXMD in this breed and one of the few cases in a female dog.
People also search for: Grand Basset Griffon Vendéen muscle problems · puppy poor movement · canine X-linked muscular dystrophy symptoms
Abstract
Three related Grand Basset Griffon Vendéen (GBGV) dogs, two male and one female, with poor locomotion and muscle pain on palpation, were humanely destroyed at approximately 2 months of age and submitted for necropsy. Histopathological examination of skeletal muscles showed hyaline hypereosinophilic myofibres, hypertrophy and atrophy, calcification, necrosis, and mild proliferation of endomyseal connective tissue, as well as small basophilic fibres with internalized nuclei in rows, indicating regeneration. Immunohistochemical labelling for the carboxy-terminal domain of dystrophin, performed on skeletal muscle from one of the male dogs, was negative, whereas it was positive in skeletal muscle from a normal control dog. Both parents were clinically unaffected. These findings confirmed the diagnosis of canine X-linked muscular dystrophy (CXMD). To the authors' knowledge, this is the first report of CXMD in the GBGV breed, and one of very few cases in a female dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17888939/