Peer-reviewed veterinary case report
Captopril lowers bladder and ureter scarring in newborn dogs
By Shirazi, Mehdi et al.·Published in Scandinavian journal of urology and nephrology·2008·Department of Surgery·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Captopril reduces deposition of collagen in lamina propria and muscular layers of the bladder and ureter in neonatal dogs with partial urethral obstruction.
- Species:
- dog
Plain-English summary
A group of neonatal dogs with partial urethral obstruction (PUO) were given a medication called captopril to see if it could help reduce collagen buildup in their bladder and ureter. After six weeks, the dogs that received captopril had less collagen in the bladder and ureter compared to those that did not receive treatment. This suggests that captopril may help manage bladder function in young dogs with this condition. However, further studies would be needed to see how this impacts their overall health and recovery.
People also search for: neonatal dog urethral obstruction treatment · captopril for dogs bladder issues · puppy bladder problems treatment
Abstract
OBJECTIVE: It has been recognized that most boys with posterior urethral valve ablation have varying degrees of ureteral dilation and abnormal bladder function. It has been shown that deposition of collagen in the bladder layers increases the intravesical pressure that is transmitted to the pelvicalyceal system. The purpose of this study was to evaluate, using stereological methods, the effect of captopril on prevention of collagen formation in different layers of the ureter and bladder under conditions of partial urethral obstruction (PUO). MATERIAL AND METHODS: PUO was induced in 10 neonatal dogs. These animals were then divided into two equal groups: the experimental group received captopril (35 mg/kg/day) and the positive control group received no treatment. After 6 weeks, the neonatal dogs underwent left nephroureterectomy and cystectomy. The ureter and bladder volumes, the volume fraction and absolute volume of the histological parameters of the ureter and bladder, the collagen content of the lamina propria, muscular and adventitial layers, and the muscle content of the muscular layer were estimated using stereological methods. RESULTS: The ureter and bladder volumes, the volumes of the layers including mucosa, lamina propria and muscular layer adventitia, the muscle content of the muscular layer and the collagen content of the adventitial layer did not show any significant differences between the groups. The collagen content (absolute volume) of lamina propria and muscular layer in the experimental group was lower than that in the positive control group for both the ureter and bladder. CONCLUSION: Administration of captopril decreases the collagen content of the lamina propria and muscular layer in the ureter and bladder of neonatal dogs with PUO.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19230165/