Peer-reviewed veterinary case report
Dog with heart tumor and adrenal gland growths like Carney complex
By Adissu, H A et al.·Published in Veterinary pathology·2010·Department of Pathobiology, Canada·View original on PubMed →
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Original publication title: Cardiac myxosarcoma with adrenal adenoma and pituitary hyperplasia resembling Carney complex in a dog.
- Species:
- dog
Plain-English summary
A 9-year-old female Golden Retriever was brought in for sudden breathing problems. Tests showed a mass in her heart that was blocking blood flow, along with other growths in her adrenal glands and pituitary gland. Unfortunately, the mass was diagnosed as a type of cancer called myxosarcoma, and despite further testing, no genetic mutations were found that could explain her condition. Sadly, the prognosis for this dog was poor due to the severity of her health issues.
People also search for: dog breathing problems · Golden Retriever heart tumor · myxosarcoma treatment in dogs
Abstract
A 9-year-old female Golden Retriever was presented with an acute onset of progressive respiratory distress. Echocardiography revealed a left atrial mass that limited blood flow from the pulmonary veins. The pathological evaluation revealed a left atrial ossifying myxosarcoma, bilateral adrenocortical adenomas, multifocal pituitary hyperplasia with expression of adrenocorticotrophic hormone, and multiple pituitary Rathke's cleft cysts. These pathologic findings are similar to those described in Carney complex, a familial human syndrome characterized by cardiac myxoma and extracardiac tumors associated with mutations in the protein kinase A regulator gene PRKAR1A. Mutations were not detected in PRKAR1A exons in the present case.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20110224/