Peer-reviewed veterinary case report
Heart injury and inflammation markers in dogs with severe pulmonic
By Saunders, Ashley B et al.·Published in Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2009·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Cardiac troponin I and C-reactive protein concentrations in dogs with severe pulmonic stenosis before and after balloon valvuloplasty.
- Species:
- dog
Plain-English summary
A group of dogs with severe pulmonic stenosis (a heart condition) had their blood tested for cardiac troponin I and C-reactive protein levels before and after a procedure called balloon valvuloplasty to improve blood flow. The tests showed that many of these dogs had elevated levels of both markers, indicating heart muscle damage and inflammation. After the procedure, the levels of these markers increased significantly, suggesting that while the surgery may help, it also causes some stress to the heart. Further research is needed to understand how these markers relate to the severity of the condition and how they can help guide treatment.
People also search for: dog heart condition treatment · pulmonic stenosis in dogs · balloon valvuloplasty for dogs
Abstract
OBJECTIVE: To report cardiac troponin I (cTnI) and C-reactive protein (CRP) concentrations in dogs with severe pulmonic stenosis (PS) before and after balloon valvuloplasty (BV). BACKGROUND: Increased morbidity and mortality have been reported with severe PS and histopathologic evidence of myocardial damage is demonstrated with BV. Severity of myocardial injury and inflammation associated with severe PS and BV, as assessed by cTnI and CRP, is unknown. ANIMALS, MATERIALS AND METHODS: Serum cTnI and CRP concentrations were measured in dogs with severe PS (n=23) and following BV (n=16). RESULTS: Baseline cTnI and CRP were elevated in 7/23 (30.4%) and 8/23 (34.8%) dogs. Median cTnI at baseline and post-BV were 0.20 ng/mL(range, 0.20-1.29 ng/mL) and 2.85 ng/mL (range, 0.21-55.40 ng/mL), respectively. Median CRP at baseline and post-BV were 3.40 microg/mL (range, 0-14.70 microg/mL) and 11.70 microg/mL (range, 4.20-120 microg/mL), respectively. Post-BV concentrations were significantly increased compared to baseline for cTnI (p<0.001) and CRP (p=0.001). CONCLUSIONS: Serum cTnI and CRP are increased in dogs with severe PS and following BV. Future studies should evaluate whether biomarkers correlate with severity and prognosis of PS or can be used to guide therapy.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19473901/