Peer-reviewed veterinary case report
Cardiac troponin I levels in healthy and heart disease cats
By Hanås, Sofia et al.·Published in Journal of feline medicine and surgery·2022·Department of Clinical Sciences·View original on PubMed →
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Original publication title: Cardiac troponin I in healthy Norwegian Forest Cat, Birman and domestic shorthair cats, and in cats with hypertrophic cardiomyopathy.
- Species:
- cat
Plain-English summary
A study looked at heart health in different breeds of cats, including Norwegian Forest Cats, Birman cats, and domestic shorthairs. Researchers measured a protein called cardiac troponin I (cTnI) in healthy cats and found that Birman cats had higher levels than Norwegian Forest Cats. They also discovered that cats with hypertrophic cardiomyopathy (HCM), a condition that thickens the heart muscle, had significantly higher cTnI levels compared to healthy cats, and those with more severe HCM had even higher levels. This suggests that cTnI could be a useful marker for assessing heart health in cats, especially for those with HCM.
People also search for: cat heart problems · hypertrophic cardiomyopathy in cats · Birman cat health issues · elevated cardiac troponin in cats
Abstract
OBJECTIVES: The aims of this study were to assess the potential associations between the serum cardiac troponin I (cTnI) concentration in healthy cats and feline characteristics, systolic blood pressure, heart rate (HR), echocardiographic measurements and storage time; and to compare cTnI concentrations in healthy cats with concentrations in cats with hypertrophic cardiomyopathy (HCM), with or without left atrial enlargement (LAE) and in cats with HCM, to assess potential associations between cTnI concentration and echocardiographic variables. METHODS: Cardiac TnI was analysed using an Abbott ARCHITECT ci16200 analyser in serum from prospectively included healthy Norwegian Forest Cat (NF; n = 33), Birman (n = 33) and domestic shorthair (DSH; n = 30) cats, and from 39 cats with HCM, with or without LAE. RESULTS: In healthy cats, higher cTnI concentrations were found in Birman cats than in NF cats ( = 0.014) and in neutered male cats than in intact females ( = 0.032). Cardiac TnI was positively associated with HR (<0.0001). In cats with HCM, cTnI concentration was positively associated with left ventricular wall thickness and with left atrial-to-aortic root ratio (all⩽0.010). Cats with HCM had higher cTnI concentrations than healthy cats, and cTnI concentrations were higher in cats with HCM and LAE than in those with HCM without LAE (all = 0.0003). CONCLUSIONS AND RELEVANCE: Breed and sex may affect serum cTnI concentrations in healthy cats. The cTnI concentration increased with increasing severity of HCM.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36073987/