Heart and breathing effects of dexmedetomidine-tiletamine anesthesia

Abstract

The aim of the present study was to evaluate the anesthetic and cardiopulmonary effects of dexmedetomidine in combination with tiletamine (without zolazepam) as a general anesthetic. The study was divided into two phases. In Phase 1, 18 adult healthy mixed-breed dogs were randomly allocated into three groups: Group TD8 (4.5 mg kgtiletamine and 8 μg kgdexmedetomidine), Group TD10 (4.5 mg kgtiletamine and 10 μg kgdexmedetomidine), or Group TD12 (4.5 mg kgtiletamine and 12 μg kgdexmedetomidine). After drug administration, the heart rate (HR), respiratory rate (), mean arterial pressure (MAP), systolic arterial pressure (SAP), diastolic arterial pressure (DAP), peripheral hemoglobin oxygen saturation (SpO), behavioral score, quality of induction and recovery, extent of ataxia, the time taken for induction, and the duration of anesthesia were recorded. The recovery time and quality were recorded after administration of atipamezole (50 μg kg) after 60 min. In phase 2, the feasibility of combining dexmedetomidine (10 μg kg) and tiletamine (4.5 mg kg) as general anesthetics for orchiectomy was evaluated in dogs (= 6). HR,, MAP, SAP, DAP, temperature, SpO, behavioral scores, and adverse reactions were recorded during each surgical procedure. In phase 1, the dogs were anesthetized for 5 min after administration of drugs and achieved a maximum behavioral score in TD10 and TD12 after 10 min. Although HR, MAP, SAP, DAP, and NIBP decreased in all three groups, they still maintained within the normal range. In phase 2, orchiectomy was completed smoothly in all dogs with little fluctuation in the physiological variables. We found that a combination of tiletamine (4.5 mg kg) and dexmedetomidine (10 μg kg) intramuscularly induced moderate anesthesia in dogs and could be utilized for short-term anesthesia and minor surgery.