Peer-reviewed veterinary case report
Heart and blood pressure effects of intubation in anesthetized Beagles
By Riccó, Carolina H & Henao-Guerrero, Natalia·Published in Journal of the American Veterinary Medical Association·2014·Department of Small Animal Clinical Sciences·View original on PubMed →
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Original publication title: Cardiovascular effects of orotracheal intubation following anesthetic induction with propofol, ketamine-propofol, or ketamine-diazepam in premedicated dogs.
- Species:
- dog
Plain-English summary
Ten healthy adult Beagles were given different combinations of anesthesia before undergoing orotracheal intubation, a procedure where a tube is placed in the airway to help with breathing. The study found that while all dogs experienced a drop in blood pressure after intubation, those that received a combination of ketamine and diazepam showed a temporary spike in blood pressure shortly after the procedure. This suggests that for dogs at risk of high blood pressure, using propofol or a mix of ketamine and propofol might be safer options for anesthesia before intubation.
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Abstract
OBJECTIVE: To compare the hemodynamic responses to orotracheal intubation following induction of anesthesia with propofol, ketamine-propofol, and ketamine-diazepam in premedicated dogs. DESIGN: Prospective, randomized, masked study. ANIMALS: 10 healthy adult Beagles. PROCEDURES: Dogs were randomly allocated to be anesthetized twice, with a 1-week wash-out interval, by means of 2 of 3 possible protocols (propofol [4 mg/kg {1.8 mg/lb}, n = 6 dogs], ketamine [2 mg/kg {0.9 mg/lb}] and propofol [2 mg/kg; 7], or ketamine [5 mg/kg {2.3 mg/lb}] and diazepam [0.2 mg/kg {0.09 mg/lb}; 6]). After instrumentation, continuous heart rate, systolic arterial blood pressure, mean arterial blood pressure, diastolic arterial blood pressure, cardiac index, stroke volume index, and systemic vascular resistance were recorded. Fifteen minutes after premedication, dogs were anesthetized; all anesthetics were administered IV. After 5 minutes, orotracheal intubation was performed without the use of a laryngoscope. Data were collected prior to intubation (baseline), at intubation, and 30, 60, 90, 120, 150, and 180 seconds thereafter. Results were compared among the 3 groups and over time. RESULTS: No differences among groups were observed for any variables studied. In all groups, arterial blood pressures were significantly decreased at various time points after intubation. A significant increase in systolic arterial blood pressure was observed between baseline and the 30-second time point in the ketamine-diazepam group. No significant differences were detected over time for the other variables in any group. CONCLUSIONS AND CLINICAL RELEVANCE: Intubation after anesthetic induction with ketamine-diazepam caused transitory hypertension, whereas intubation after induction with propofol or ketamine-propofol did not cause cardiovascular stimulation. In dogs in which hypertension is a concern, propofol or ketamine-propofol may be a better choice for induction prior to orotracheal intubation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24697769/