Peer-reviewed veterinary case report
Heart and blood pressure effects of 10% eye drops in dogs
By Herring, I P et al.·Published in Veterinary ophthalmology·2004·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Cardiovascular effects of topical ophthalmic 10% phenylephrine in dogs.
- Species:
- dog
Plain-English summary
A group of nine healthy dogs had their heart rates and blood pressure monitored after receiving eye drops containing 10% phenylephrine. The dogs were given either one drop or three drops of the medication in each eye, and their vital signs were checked for 90 minutes afterward. The results showed that the dogs experienced an increase in blood pressure and a decrease in heart rate after the treatment. This means that while the eye drops were effective in raising blood pressure, they also caused the heart to beat more slowly.
People also search for: dog eye drops side effects · phenylephrine for dogs · dog heart rate changes after medication
Abstract
OBJECTIVE: To evaluate the effect of topical ophthalmic 10% phenylephrine on systolic arterial pressure (SAP), diastolic arterial pressure (DAP), mean arterial pressure (MAP), pulse rate (PR) and electrocardiogram (ECG) in dogs. ANIMALS STUDIED: Nine clinically normal dogs. PROCEDURE: Arterial catheters were placed in the dorsal pedal artery of awake dogs and ECG leads were attached. After a 15-min acclimatization period, baseline PR, SAP, DAP and MAP were recorded every 5 min for 20 min. Two treatment groups (eight dogs each) were studied. Group I: one drop of phenylephrine was placed in each eye once. Group II: one drop of phenylephrine was placed in each eye three times at 5-min intervals. Following treatment, PR, SAP, DAP and MAP were recorded every 5 min for 90 min. The mixed procedure of the SAS system was used to perform a repeated measures analysis of variance to test for linear and quadratic trends across time. RESULTS: Group I: There was a significant quadratic decrease in PR across time (P = 0.0051). Systolic arterial pressure increased linearly with time (P = 0.0002), MAP increased linearly with time (P = 0.0131), and DAP increased linearly with time (P = 0.0001). Group II: There was a significant quadratic decrease in PR across time (P = 0.0023). There was a significant quadratic increase in SAP (P = 0.0324), MAP (P = 0.0103) and DAP (P = 0.0131) across time. CONCLUSIONS: Topical ophthalmic application of 10% phenylephrine in normal dogs results in elevation of arterial blood pressure and reflex bradycardia.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/14738506/