Peer-reviewed veterinary case report
Carprofen and buprenorphine stop inflammation pain in cats
By Taylor, P M et al.·Published in Research in veterinary science·2007·Taylor Monroe, United Kingdom·View original on PubMed →
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Original publication title: Carprofen and buprenorphine prevent hyperalgesia in a model of inflammatory pain in cats.
- Species:
- cat
Plain-English summary
A group of eight cats were tested to see how well two pain medications, carprofen and buprenorphine, could help with pain caused by inflammation. After receiving either medication or a saline solution, the cats had a mild inflammation induced, and their pain sensitivity was measured. The results showed that carprofen effectively kept the cats' pain levels stable, while buprenorphine worked well but showed some sensitivity at the two-hour mark. Overall, both medications helped prevent increased pain sensitivity from inflammation, with carprofen being the most effective.
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Abstract
A model of nociceptive threshold determination was developed for evaluation of NSAID analgesia in cats. In a crossover study, eight cats received carprofen (4 mg/kg), buprenorphine (0.01 mg/kg) or saline (0.3 ml) subcutaneously before intradermal kaolin injection on the antebrachium to induce mild inflammation. Pressure thresholds were measured at the injected site using blunt-ended pins advanced by manual inflation of a bladder within a bracelet. Bladder pressure was recorded as threshold (PT) at the behavioural end point. Baseline PT were recorded before kaolin injection (time 0). PT was measured at 2-10 h intervals for 52 h. PT below the lower 95% confidence interval (CI) of baseline values indicated hyperalgesia. After saline, hyperalgesia was detected from 2-6 h, 22-26 h, and at 30 and 36 h. After carprofen, PT remained within the 95% CI. After buprenorphine, PT remained within the 95% CI except at 2h. Carprofen and to some extent buprenorphine, prevented inflammatory hyperalgesia.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17363018/