Peer-reviewed veterinary case report
Kidney development problems in a 3-month-old female Welsh Corgi puppy
By Le, Trung Quang et al.·Published in Frontiers in veterinary science·2022·Department of Veterinary Pathology·View original on PubMed →
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Original publication title: Case report: BCL-2 and CD31 immunoexpression related to clinical and histopathological evaluation of renal dysplasia in a Welsh Corgi Puppy.
- Species:
- dog
Plain-English summary
A 3-month-old female Welsh Corgi puppy was brought in with unclear signs of chronic kidney disease, which can include symptoms like increased thirst and urination. Upon examination, the vet found that both kidneys were underdeveloped and had cysts. Further tests revealed immature kidney structures and signs of inflammation and damage in the kidney tissue. Unfortunately, this condition, known as renal dysplasia, is serious and can lead to ongoing kidney issues. The puppy's specific treatment options would depend on the severity of her symptoms and overall health.
People also search for: Welsh Corgi puppy kidney disease symptoms · chronic kidney disease in dogs · renal dysplasia treatment for dogs
Abstract
A case of renal dysplasia (RD) in the Welsh Corgi dog has been reported. Clinically, the affected 3-month-old, female, Welsh Corgi dog showed unclear symptoms of chronic kidney disease. Grossly, both left and right kidneys revealed cystic hypoplasia. Histologically, the primary lesions included immature or fetal glomeruli/tubules, proliferative arterioles, persistent metanephric ducts, persistent mesenchyme, and atypical tubular epithelium were presented. A group of degenerative and inflammatory lesions consisting of interstitial nephritis, interstitial fibrosis, and mineralization of tubules were found. Immunohistochemically, the epithelial cells of immature (fetal) tubules had BCL-2 labeling whereas CD31 (PECAM-1) was labeled in the endothelial cells of the proliferative arterioles. The immunohistochemical findings were confirmed and consolidated with the routine histopathological findings. This study was the first demonstration of the clinical, histopathological, and immunohistochemical features of RD disease in a Welsh Corgi puppy.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36268045/