Peer-reviewed veterinary case report
Miniature Schnauzer dog with low thyroid and high cortisol hormone
By Chae, Yeon et al.·Published in Frontiers in veterinary science·2023·College of Veterinary Medicine, South Korea·View original on PubMed →
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Original publication title: Case report: Central-pituitary hypothyroidism concurrent with hyperadrenocorticism without pituitary macroadenoma in a Miniature Schnauzer dog.
- Species:
- dog
Plain-English summary
A 7-year-old female Miniature Schnauzer was brought in for hair loss, scaling, and itching. After running tests, the veterinarian found that the dog had two hormonal disorders: hyperadrenocorticism (Cushing's disease) and central-pituitary hypothyroidism (a type of thyroid deficiency). The vet first treated the Cushing's disease to help manage the symptoms, and once that was under control, they added treatment for the hypothyroidism. After about nine months of treatment, the dog's conditions were well managed, and her symptoms improved significantly, although some thyroid hormone levels remained low.
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Abstract
Multiple endocrine disorders are uncommon in veterinary medicine, and the disease combination is usually related to hypercortisolism or autoimmunity. Central-pituitary hypothyroidism, also refer to secondary hypothyroidism, can be caused by hypercortisolemic conditions and is well-recognized in human medicine. However, central hypothyroidism, including pituitary hypothyroidism, concurrent with hyperadrenocorticism, is rarely reported in veterinary medicine. A 7-year-old, intact female Miniature Schnauzer presented with generalized alopecia, scale, and pruritus and was diagnosed with superficial pyoderma anddermatitis. Hormonal tests were performed, and the results indicated multiple endocrinopathies with a combination of non-adrenal dependent hyperadrenocorticism and central-pituitary hypothyroidism. Magnetic resonance imaging (7 T) and high-resolution research tomography positron emission tomography were performed to differentiate neuroendocrine tumors; however, no lesion was found in the hypothalamic to pituitary region. Hyperadrenocorticism was managed first to control endocrinopathy. After controlling hypercortisolism, a weak elevation of free thyroxine (T4) was revealed, whereas total T4 and thyroid-stimulating hormone (TSH) were still undetectable, and hypothyroidism management was added. About 9 months after the management, both endocrine diseases were well controlled, and clinical signs improved; however, serum TSH was unmeasured consistently. This case study describes a case of multiple endocrinopathies in a Miniature Schnauzer dog diagnosed with central-pituitary hypothyroidism concurrent with non-adrenal dependent hyperadrenocorticism without pituitary macroadenoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37818388/