Peer-reviewed veterinary case report
Dog with metastatic nasal cancer and severe bleeding disorder
By Granger, Kyle L et al.·Published in Frontiers in veterinary science·2024·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Case report: Chronic disseminated intravascular coagulopathy with concurrent paraneoplastic secondary hyperfibrinolysis in a dog with metastatic nasal adenocarcinoma.
- Species:
- dog
Plain-English summary
An 8-year-old neutered male Border Collie was brought to the vet for severe nosebleeds that kept coming back. He had been treated for nasal cancer for a year, and tests showed he had a serious bleeding disorder linked to his cancer. The dog received various treatments, including blood products and medications to help with clotting, but his condition didn't improve. Sadly, he was euthanized the day after going home because he was not doing well. This case highlights the need for vets to consider bleeding disorders in dogs with nasal cancer.
People also search for: dog nosebleeds · Border Collie cancer treatment · dog bleeding disorder · nasal adenocarcinoma in dogs · dog quality of life after cancer
Abstract
In human medicine, hemostatic disorders such as thrombocytopenia, hyperfibrinolysis, and disseminated intravascular coagulopathy (DIC) have been associated with many cancers. Acute hemorrhage secondary to hyperfibrinolysis has been predominantly reported with prostatic adenocarcinoma in human patients. To the author's knowledge, severe bleeding due to paraneoplastic hyperfibrinolysis has not yet been reported in veterinary medicine. The case involves an 8-year-old neutered male Border Collie who was evaluated for progressive and recurrent epistaxis, having a history of 1 year of treatment for metastatic nasal adenocarcinoma. A progressive and severe coagulopathy thought to be related to the known cancer was diagnosed. Advanced coagulation testing was consistent with a chronic DIC and secondary hyperfibrinolysis. Throughout 1 week of hospitalization, the dog was treated with multiple blood products, vitamin K, and anti-fibrinolytic medications. While the dog was initially discharged home, the dog re-presented the following day and was humanely euthanized due to a perceived poor quality of life. Post-mortem analysis revealed a histopathologic diagnosis of disseminated adenocarcinoma. In dogs with disseminated nasal adenocarcinoma that are experiencing severe bleeding, paraneoplastic secondary hyperfibrinolysis should be considered as a differential. Knowing this association could help guide treatment recommendations for optimal patient management.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38840638/