Peer-reviewed veterinary case report
Dog with nasal cancer bleeding from blood clotting disorder
By Kyle L. Granger et al.·Published in Frontiers in Veterinary Science·2024·View original on Semantic Scholar →
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Original publication title: Case report: Chronic disseminated intravascular coagulopathy with concurrent paraneoplastic secondary hyperfibrinolysis in a dog with metastatic nasal adenocarcinoma
- Species:
- dog
Plain-English summary
An 8-year-old neutered male Border Collie was brought to the vet for severe nosebleeds that had been getting worse over the past year due to metastatic nasal adenocarcinoma (a type of cancer). Tests showed he had a serious bleeding disorder linked to his cancer. During a week in the hospital, he received blood products, vitamin K1, and medications to help with the bleeding. Although he was sent home, he returned the next day and was sadly euthanized because his quality of life had declined. A post-mortem exam confirmed the cancer diagnosis.
People also search for: dog nosebleeds · Border Collie cancer treatment · dog bleeding disorder · metastatic nasal adenocarcinoma in dogs
Abstract
In human medicine, hemostatic disorders such as thrombocytopenia, hyperfibrinolysis, and disseminated intravascular coagulopathy (DIC) have been associated with many cancers. Acute hemorrhage secondary to hyperfibrinolysis has been predominantly reported with prostatic adenocarcinoma in human patients. To the author’s knowledge, severe bleeding due to paraneoplastic hyperfibrinolysis has not yet been reported in veterinary medicine. The case involves an 8-year-old neutered male Border Collie who was evaluated for progressive and recurrent epistaxis, having a history of 1 year of treatment for metastatic nasal adenocarcinoma. A progressive and severe coagulopathy thought to be related to the known cancer was diagnosed. Advanced coagulation testing was consistent with a chronic DIC and secondary hyperfibrinolysis. Throughout 1 week of hospitalization, the dog was treated with multiple blood products, vitamin K1, and anti-fibrinolytic medications. While the dog was initially discharged home, the dog re-presented the following day and was humanely euthanized due to a perceived poor quality of life. Post-mortem analysis revealed a histopathologic diagnosis of disseminated adenocarcinoma. In dogs with disseminated nasal adenocarcinoma that are experiencing severe bleeding, paraneoplastic secondary hyperfibrinolysis should be considered as a differential. Knowing this association could help guide treatment recommendations for optimal patient management.
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Search related cases →Original publication on Semantic Scholar: https://www.semanticscholar.org/paper/38840638