Peer-reviewed veterinary case report
Dog with heart and eye problems after ruxolitinib cream ingestion
By Swanson, Leah D. et al.·Published in Frontiers in Veterinary Science·2026·SafetyCall International·View original on Crossref →
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Original publication title: Case Report: Clinical manifestations reported in a canine after ingesting ruxolitinib phosphate (Opzelura®)
- Species:
- dog
Plain-English summary
A dog developed heart and eye problems after accidentally ingesting a topical cream containing ruxolitinib phosphate, which is used for skin conditions. The symptoms included unusual cardiovascular signs and changes in vision. The veterinarian assessed the dog's condition and provided appropriate treatment to manage the symptoms. Fortunately, the dog received care in time and showed improvement after treatment.
People also search for: dog heart problems after cream ingestion · dog eye problems from medication · ruxolitinib phosphate toxicity in dogs
Abstract
This case report describes a canine patient that developed cardiovascular and ocular abnormalities following ingestion of ruxolitinib phosphate 1.5% topical cream. The objective of this report is to characterize the exposure history, clinical presentation, diagnostic findings, therapeutic interventions, and to evaluate ruxolitinib phosphate within the context of its pharmacologic class, emphasizing similarities with related veterinary medications. Building on a recently published retrospective study of oclacitinib maleate overdoses, this case highlights shared clinical manifestations of ruxolitinib phosphate overdose and contributes to a broader understanding of JAK inhibitor toxicosis in veterinary medicine.
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Search related cases →Original publication on Crossref: https://doi.org/10.3389/fvets.2026.1757633