Peer-reviewed veterinary case report
Dog with heart and eye problems after swallowing ruxolitinib cream
By Swanson, Leah D et al.·Published in Frontiers in veterinary science·2026·SafetyCall International, United States·View original on PubMed →
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Original publication title: Case Report: Clinical manifestations reported in a canine after ingesting ruxolitinib phosphate (Opzelura).
- Species:
- dog
Plain-English summary
A dog developed heart and eye problems after accidentally ingesting a topical cream containing ruxolitinib phosphate. The owner noticed unusual symptoms and took the dog to the vet, where it was diagnosed with cardiovascular and ocular issues related to the cream. The veterinarian provided treatment to address these symptoms and monitor the dog's recovery. Thankfully, the dog received appropriate care and improved over time.
People also search for: dog heart problems after eating cream · dog eye issues from medication · ruxolitinib phosphate toxicity in dogs
Abstract
This case report describes a canine patient that developed cardiovascular and ocular abnormalities following ingestion of ruxolitinib phosphate 1.5% topical cream. The objective of this report is to characterize the exposure history, clinical presentation, diagnostic findings, therapeutic interventions, and to evaluate ruxolitinib phosphate within the context of its pharmacologic class, emphasizing similarities with related veterinary medications. Building on a recently published retrospective study of oclacitinib maleate overdoses, this case highlights shared clinical manifestations of ruxolitinib phosphate overdose and contributes to a broader understanding of JAK inhibitor toxicosis in veterinary medicine.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41767678/