Peer-reviewed veterinary case report
Fundic gland polyps linked to long-term omeprazole in Maltese dog
By Haemin Lee et al.·Published in Frontiers in Veterinary Science·2023·View original on Semantic Scholar →
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Original publication title: Case report: Fundic gland polyps caused by long-term omeprazole use in a Maltese dog
- Species:
- dog
Plain-English summary
A 5-year-old Maltese dog was brought to the vet because she was experiencing chronic vomiting. She had been taking omeprazole, a medication often used to reduce stomach acid, for over four years to manage a condition called hydrocephalus. After some tests, the vet found thickening in her stomach lining and polyps, which are abnormal growths. Once the medication was stopped, her symptoms improved, and follow-up imaging showed that the polyps had resolved.
People also search for: Maltese dog vomiting treatment · omeprazole side effects in dogs · dog stomach polyps symptoms
Abstract
Long-term use of proton-pump inhibitors can induce fundic gland polyps in the human stomach. However, this phenomenon has not been described in the veterinary literature. A 5-year-old intact female Maltese dog was referred to our hospital with chronic intermittent vomiting. The dog had been administered omeprazole (0.7–1.0 mg/kg PO q24 h) for the management of hydrocephalus for over 4 years; the omeprazole dose was increased to 10 mg/kg PO q24 h 8 months prior to presentation at referring hospital. Abdominal ultrasonography revealed marked thickening of the gastric wall with multi-lobulated, thickened folds. Subsequent endoscopy revealed marked polypoid lesions, and histological examination of the biopsy samples was consistent with the fundic gland polyps associated with proton-pump inhibitor use in humans. The lesions resolved after cessation of omeprazole, as assessed by ultrasonography. This report describes a case of fundic gland polyps following the long-term administration of omeprazole in a dog.
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Search related cases →Original publication on Semantic Scholar: https://www.semanticscholar.org/paper/37937150