Peer-reviewed veterinary case report
Rare nerve tumor causing spinal pain and lameness in adult dogs
By Yin, Ji-Hang et al.·Published in Frontiers in veterinary science·2023·Department of Pathobiology, United States·View original on PubMed →
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Original publication title: Case report: Intraneural perineurioma in dogs: a case series and brief literature review.
- Species:
- dog
Plain-English summary
A 5-year-old male dog was diagnosed with a rare tumor called intraneural perineurioma after showing signs of spinal pain, limping, and weakness in his legs. This type of tumor affects the nerves and can lead to significant discomfort and mobility issues. The diagnosis was confirmed through specific tests that revealed unique patterns in the tumor cells. While the treatment options for this condition are not well-established, understanding its characteristics can help veterinarians provide better care for affected dogs.
People also search for: dog spinal pain causes · limping dog tumor treatment · canine nerve tumor symptoms
Abstract
Intraneural perineurioma is an exceptionally rare neoplasm in animals. This case study comprises a series of three cases and a brief literature review focusing on canine intraneural perineurioma. The pathological and immunohistochemical findings are documented, revealing that canine intraneural perineurioma frequently affects adult dogs aged between 3 and 10 years old, with a male predominance. Clinical signs associated with intraneural perineurioma in dogs include spinal pain, lameness, and paresis, resulting from the involvement of spinal nerve roots of the pelvic limbs, brachial plexus, or distal part of the median nerve. Most neoplasms had characteristic pseudo-onion bulb patterns on histopathology. Neoplastic perineurial cells, in most cases, expressed laminin and claudin-1, and NF200 consistently highlighted the central axon. While the immunohistochemical (IHC) profile of intraneural perineurioma in veterinary medicine remains incompletely characterized, the available IHC data from all reported cases suggest that a combination of laminin and claudin-1 immunomarkers, along with distinctive histological features, can assist in establishing a definitive diagnosis of intraneural perineurioma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38274660/