Peer-reviewed veterinary case report
Two dogs with brain inflammation later developed mineralized lung
By Rosen, Suzanne et al.·Published in Frontiers in veterinary science·2020·School of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: Case Report: Mineralized Pulmonary Artery Thrombi in Two Dogs Treated for Meningoencephalitis of Unknown Origin.
- Species:
- dog
Plain-English summary
Two dogs diagnosed with a serious brain condition called meningoencephalitis of unknown origin (MUO) were treated with long-term corticosteroids and another medication. Despite the typically poor outlook for this condition, both dogs lived longer than expected before developing breathing problems due to mineralized clots in their lung arteries. Unfortunately, they eventually passed away from these respiratory issues. This case highlights the potential risks associated with long-term use of certain medications in dogs with MUO.
People also search for: dog meningoencephalitis treatment · breathing problems in dogs · long-term corticosteroids side effects in dogs
Abstract
Meningoencephalitis of unknown origin (MUO) is a relatively common and very serious canine neurologic condition, which is typically associated with a poor long term prognosis despite treatment. This case series chronicles two dogs diagnosed with MUO who were treated with long term corticosteroids and cytosine arabinoside and lived well-beyond the typical survival time for this condition. Both eventually succumbed to respiratory signs associated with mineralized thrombi in their pulmonary arteries. Adverse effects from the two drugs used for treatment are reviewed in order to propose a possible mechanism to explain how long term use of these medications could result in such a phenomenon.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33392278/